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Article

Intrachromosomal serial replication slippage in trans gives rise to diverse genomic rearrangements involving inversions.

Human mutation - 1 Oct 2005

Chen Jian-Min, Chuzhanova Nadia, Stenson Peter D, Férec Claude, Cooper David N

Abstract excerpt

Serial replication slippage in cis (SRScis) provides a plausible explanation for many complex genomic rearrangements that underlie human genetic disease. This concept, taken together with the intra- and intermolecular strand switch models that account for mutations that arise via quasipalindrome correction, suggest that intrachromosomal SRS in trans (SRStrans) mediated by short inverted repeats may also give rise...

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PMID: 16110485
DOI: 10.1002/humu.20230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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