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Article

Mechanisms of self-association of a human monoclonal antibody CNTO607.

Protein engineering, design & selection : PEDS - 1 Oct 2012

Bethea Deidra, Wu Sheng-Jiun, Luo Jinquan, Hyun Linus, Lacy Eilyn R, Teplyakov Alexey, Jacobs Steven A, O'Neil Karyn T, Gilliland Gary L, Feng Yiqing

Abstract excerpt

Some antibodies have a tendency to self-associate leading to precipitation at relatively low concentrations. CNTO607, a monoclonal antibody, precipitates irreversibly in phosphate-buffered saline at concentrations above 13 mg/ml. Previous mutagenesis work based on the Fab crystal structure pinpointed a three residue fragment in the heavy chain CDR-3, (99)FHW(100a), as an aggregation epitope that is anchored by...

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PMID: 22915597
DOI: 10.1093/protein/gzs047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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