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Article

Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton.

The International journal of developmental biology - 1 Feb 1995

Mark M, Lohnes D, Mendelsohn C, Dupé V, Vonesch J L, Kastner P, Rijli F, Bloch-Zupan A, Chambon P

Abstract excerpt

Retinoic acid receptors and transcriptional factors encoded by Hox genes play key roles in vertebrate development and belong to an integrated functional network. To investigate the actual functions of these molecules during ontogenesis and in particular in the patterning of the cranial neural crest cells giving rise to the teeth and to the jaw bones, we have generated null mutant mice lacking functional retinoic...

Topics

Animals
Cell Differentiation
Computer Simulation
Homeodomain Proteins
Humans
Jaw
Mesoderm
Mutation
Receptors, Retinoic Acid
Tooth
Trans-Activators

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PMID: 7626396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7626396-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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