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Article

Proliferation of cancer cells despite CDK2 inhibition.

Cancer cell - 1 Mar 2003

Tetsu Osamu, McCormick Frank

Abstract excerpt

We have investigated the contribution of CDK4 and CDK2 inhibition to G1 arrest in colon cancers following inhibition of the MEK/MAP kinase pathway. CDK4 inhibition is sufficient to cause arrest, but inhibition of CDK2 by p27 Kip1 redistribution or ectopic expression has no effect on proliferation. Likewise, inhibition of CDK2 through expression of dominant-negative (DN) CDK2 or antisense oligonucleotides did not...

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Identifiers

PMID: 12676582
DOI: 10.1016/s1535-6108(03)00053-9

Genes

CDK2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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