Article
Heparan sulfate enhances invasion by human colon carcinoma cell lines through expression of CD44 variant exon 3.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2001
Kuniyasu H, Oue N, Tsutsumi M, Tahara E, Yasui W
Abstract excerpt
CD44 variant exon (CD44v) 3 is a heparan sulfate-binding isoform of CD44. The role of CD44v3 in invasion and metastasis associated with heparan sulfate in colon cancer cell lines and cases of colon cancer was examined. Expression of CD44v3 mRNA and protein was observed in five of six human colorectal cancer cell lines. Colo320 and WiDr cells expressed CD44v3 at high levels. Heparan sulfate treatment increased the...
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