Mutations in RAD27 define a potential link between G1 cyclins and DNA replication.

doi:10.1128/MCB.15.8.4291

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Article

Mutations in RAD27 define a potential link between G1 cyclins and DNA replication.

Molecular and cellular biology - 1 Aug 1995

Vallen E A, Cross F R

Abstract excerpt

The yeast Saccharomyces cerevisiae has three G1 cyclin (CLN) genes with overlapping functions. To analyze the functions of the various CLN genes, we examined mutations that result in lethality in conjunction with loss of cln1 and cln2. We have isolated alleles of RAD27/ERC11/YKL510, the yeast homolog of the gene encoding flap endonuclease 1, FEN-1.cln1 cln2 rad27/erc11 cells arrest in S phase; this cell cycle...

Topics

Checkpoint Kinase 1
Cloning, Molecular
Cyclins
DNA Damage
DNA Replication
DNA-Binding Proteins
Endodeoxyribonucleases
Flap Endonucleases
Fungal Proteins
G1 Phase
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interphase

Mutation

Protein Kinases

S Phase

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7623823
DOI: 10.1128/MCB.15.8.4291
PMCID: PMC230668

Genes

CLN3
GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7623823-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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