Article
Dosage suppressors of the dominant G1 cyclin mutant CLN3-2: identification of a yeast gene encoding a putative RNA/ssDNA binding protein.
Molecular & general genetics : MGG - 25 Oct 1995
Sugimoto K, Matsumoto K, Kornberg R D, Reed S I, Wittenberg C
Abstract excerpt
Three G1 cyclins, CLN1, CLN2, and CLN3, have been identified in the budding yeast Saccharomyces cerevisiae. G1 cyclins are essential, albeit functionally redundant, rate-limiting activators of cell cycle initiation. We have isolated dosage-dependent suppressor genes (designated HMD genes) of the mating defect caused by CLN3-2, a dominant mutation in CLN3, HMD2 and HMD3 are identical to STE4 and STE5,...
Topics
- Amino Acid Sequence
- Cell Division
- Cyclins
- DNA, Single-Stranded
- DNA-Binding Proteins
- Fungal Proteins
- G1 Phase
- Gene Expression Regulation, Fungal
- Genes, Dominant
- Genes, Fungal
- Genes, Suppressor