Article
Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians.
Diabetes - 1 Sept 1996
Norman R A, Leibel R L, Chung W K, Power-Kehoe L, Chua S C, Knowler W C, Thompson D B, Bogardus C, Ravussin E
Abstract excerpt
The homologues of single genes that cause obesity in rodents are suggested as candidate genes for modulation of body composition in humans. Among these genes are the four mouse mutations-diabetes (db), obesity (ob), tubby (tub), and yellow agouti (Ay). Variation in the human counterparts to these genes (OB, DB, TUB, and ASP, respectively) may contribute to human obesity, which is thought to have a substantial...
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