Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians.

doi:10.2337/diab.45.9.1229

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Article

Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians.

Diabetes - 1 Sept 1996

Norman R A, Leibel R L, Chung W K, Power-Kehoe L, Chua S C, Knowler W C, Thompson D B, Bogardus C, Ravussin E

Abstract excerpt

The homologues of single genes that cause obesity in rodents are suggested as candidate genes for modulation of body composition in humans. Among these genes are the four mouse mutations-diabetes (db), obesity (ob), tubby (tub), and yellow agouti (Ay). Variation in the human counterparts to these...

Topics

Adipose Tissue
Animals
Arizona
DNA, Satellite
Diabetes Mellitus
Energy Metabolism
Ethnicity
Female
Gene Frequency
Genetic Linkage
Genetic Markers
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Indians, North American

Leptin

Male

Mice

Nuclear Family

Source

Open in PubMed

Identifiers

PMID: 8772727
DOI: 10.2337/diab.45.9.1229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8772727-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians.PMID 8772727Read ↗

Absence of linkage between human obesity and the mouse agouti homologous region (20q11.2) or other markers spanning chromosome 20q.Semantic proximity Read ↗

OB gene not linked to human obesity in Mexican American affected sib pairs from Starr County, Texas.Semantic proximity Read ↗

Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians.Semantic proximity Read ↗

Obesity in Pima Indians: genetic segregation analyses of body mass index complicated by temporal increases in obesity.Semantic proximity Read ↗

Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas.Semantic proximity Read ↗

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.Semantic proximity Read ↗

Summary of human linkage and association studies.Semantic proximity Read ↗

Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians.Semantic proximity Read ↗

Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs.Semantic proximity Read ↗

Suggestive linkages between markers on human 1p32-p22 and body fat and insulin levels in the Quebec Family Study.Semantic proximity Read ↗

The bovine homolog of the obese gene maps to Chromosome 4Semantic proximity Read ↗

The yellow agouti mutation alters some but not all responses to diet and exercise.Semantic proximity Read ↗

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