Article
Association between RB-1 gene alterations and factors of favourable prognosis in human breast cancer, without effect on survival.
International journal of cancer - 21 Apr 1995
Berns E M, de Klein A, van Putten W L, van Staveren I L, Bootsma A, Klijn J G, Foekens J A
Abstract excerpt
The retinoblastoma (RB) tumour suppressor gene has been associated not only with retinoblastoma but also with several other tumours like osteosarcoma, small cell lung carcinoma and prostate and breast cancer. We have studied the incidence of RB gene alterations in 96 primary breast tumours using Southern blotting techniques. The outcome has been related with patient and tumour characteristics, oncogene...
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