Article
An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Jan 1993
Issing W J, Wustrow T P, Oeckler R, Mezger J, Nerlich A
Abstract excerpt
A 24-year-old male patient with hereditary retinoblastoma and a poorly differentiated osteoblastic osteogenic sarcoma was found to carry a mutant RB1 allele in all cells. This findings was most likely a point mutation or microdeletion because Southern blot analysis of peripheral blood DNA failed...
Topics
- Adult
- Alleles
- Blotting, Southern
- DNA, Neoplasm
- Eye Neoplasms
- Genes, Retinoblastoma
- Humans
- Male
- Neoplasms, Multiple Primary
- Orbital Neoplasms
- Osteosarcoma
- Point Mutation
- Retinoblastoma