Article
Mutations of retinoblastoma gene (Rb-1) as a prognostic factor in children with acute leukemia and neuroblastoma.
Pediatric hematology and oncology - 1 Mar 2001
Markaki E A, Tsopanomichalou M, Dimitriou H, Stiakaki E, Perdikoyanni C, Spandidos D, Kalmanti M
Abstract excerpt
Rb-1 is a tumor suppressor gene encoding for a nuclear phosphoprotein acting as a cell cycle regulator, normally expressed in hematopoietic cells and more often inactivated by point mutations with predominance for exons 20-24. The aim of this study is to correlate the retinoblastoma-1 (Rb-1) gene mutations with the prognosis and progression of childhood acute leukemia and neuroblastoma. Bone marrow slides from 26...
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