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Genomic gains on chromosome 1q in retinoblastoma: Consequences on gene expression and association with clinical manifestation

11 Apr 2005

Abstract excerpt

Many retinoblastomas (Rbs) show genomic alterations in addition to mutational loss of both normal RB1 alleles. The most frequent of these changes are gains on chromosomes 1q and 6p and losses on 16q. To identify the genes targeted by gains on chromosome 1q, we used quantitative-multiplex PCR to determine DNA copy number changes in 76 primary tumors and 6 Rb cell lines. In addition, in 21 of these tumors, gene...

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PMID: 15825178
DOI: 10.1002/ijc.21051

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