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Article

Significance of retinoblastoma and mdm2 gene expression as prognostic markers for soft-tissue sarcoma.

Langenbeck's archives of surgery - 1 Mar 1998

Würl P, Meye A, Berger D, Lautenschläger C, Bache M, Holzhausen H J, Schmidt H, Dralle H, Rath F W, Taubert H

Abstract excerpt

The growth regulatory function of the retinoblastoma protein (RB) can be suppressed by mdm2 via RB/mdm2 interaction by perturbation of the RB suppression of the E2F function. The goal of this study was to examine the clinical value of immunohistochemical (IHC) RB detection and its relationship to mdm2 overexpression in a cohort of 198 adult primary soft-tissue sarcomas (STS). RB overexpression reveals,...

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Identifiers

PMID: 9627179
DOI: 10.1007/s004230050099

Genes

STS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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