Article
Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1998
Lens S M, den Drijver B F, Pötgens A J, Tesselaar K, van Oers M H, van Lier R A
Abstract excerpt
To dissect intracellular pathways involved in B cell Ag receptor (BCR)-mediated and Fas-induced human B cell death, we isolated clones of the Burkitt lymphoma cell line Ramos with different apoptosis sensitivities. Selection for sensitivity to Fas-induced apoptosis also selected for clones with e...
Topics
- Adaptor Proteins, Signal Transducing
- Apoptosis
- B-Lymphocytes
- Carrier Proteins
- Caspase 3
- Caspases
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- Fas-Associated Death Domain Protein
- Flow Cytometry
- Humans
- Molecular Weight
- Oligopeptides
- Phenotype
- Receptors, Antigen, B-Cell
- Tumor Cells, Cultured
- fas Receptor