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Article

Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1998

Lens S M, den Drijver B F, Pötgens A J, Tesselaar K, van Oers M H, van Lier R A

Abstract excerpt

To dissect intracellular pathways involved in B cell Ag receptor (BCR)-mediated and Fas-induced human B cell death, we isolated clones of the Burkitt lymphoma cell line Ramos with different apoptosis sensitivities. Selection for sensitivity to Fas-induced apoptosis also selected for clones with enhanced BCR death sensitivity and vice versa. In contrast, clones resistant to Fas-mediated apoptosis could still...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9637525

Genes

BCR
FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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