Article
A Dictyostelium anterior-like cell mutant reveals sequential steps in the prespore prestalk differentiation pathway.
Development (Cambridge, England) - 1 Oct 1994
Bichler G, Weijer C J
Abstract excerpt
We have isolated Dictyostelium cell type proportioning mutants in a screen for cAMP signal transduction mutants. All mutants showed reduced numbers of prespore cells as analyzed with prespore-specific antibodies and prespore- and prestalk-specific reporter gene constructs. Formation of prestalk and prespore cells in the mutant HP1 is initially almost normal; however, many prespore cells redifferentiate as...
Topics
- Animals
- Cell Differentiation
- Cyclic AMP
- Dictyostelium
- Genes, Reporter
- Mutation
- Signal Transduction
- Spores