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Article

Mechanisms of allele-selective down-regulation of HLA class I in Burkitt's lymphoma.

International journal of cancer - 4 Jul 1995

Imreh M P, Zhang Q J, de Campos-Lima P O, Imreh S, Krausa P, Browning M, Klein G, Masucci M G

Abstract excerpt

Burkitt lymphomas (BL) that arise in HLA-AII-positive individuals are characterized by selective loss/down-regulation of the HLA AII polypeptide. We have investigated the molecular basis of such down-regulation by comparing 5 pairs of BL lines and Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCL) derived from the normal B cells of the same individuals. The presence of apparently intact HLA AII...

Topics

Alleles
Base Sequence
Burkitt Lymphoma
Down-Regulation
HLA-A Antigens
HLA-A11 Antigen
Humans
Molecular Sequence Data
Promoter Regions, Genetic
RNA, Messenger
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7601573
DOI: 10.1002/ijc.2910620117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7601573-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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