Article
Immune escape by Epstein-Barr virus (EBV) carrying Burkitt's lymphoma: in vitro reconstitution of sensitivity to EBV-specific cytotoxic T cells.
International immunology - 1 Nov 1992
Masucci M G, Zhang Q J, Gavioli R, De Campos-Lima P O, Murray R J, Brooks J, Griffin H, Ploegh H, Rickinson A B
Abstract excerpt
Epstein-Barr virus (EBV) positive Burkitt's lymphoma (BL) cells are markedly less sensitive to EBV-specific cytotoxic T cell (CTL) recognition than EBV-transformed lymphoblastoid cell lines of normal B cell origin. Three features of the BL cell phenotype might contribute to this reduced susceptibility: (i) low expression of cell adhesion molecules, (ii) low expression of HLA class I and selective down-regulation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
