The PML gene is linked to a megabase-scale insertion/deletion restriction fragment length polymorphism.

doi:10.1016/0888-7543(95)80217-a

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Article

The PML gene is linked to a megabase-scale insertion/deletion restriction fragment length polymorphism.

Genomics - 20 Mar 1995

Goy A, Passalaris T, Xiao Y H, Miller W H, Siegel D S, Zelenetz A D

Abstract excerpt

The PML gene located on chromosome band 15q22 is involved with the RAR alpha locus (17q21) in a balanced reciprocal translocation uniquely observed in acute promyelocytic leukemia. Physical mapping studies by pulsed-field gel electrophoresis revealed that the PML gene is flanked by two CpG island...

Topics

Alleles
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
Deoxyribonucleases, Type II Site-Specific
Electrophoresis, Gel, Pulsed-Field
Genes
Genetic Linkage
Humans
Leukemia, Promyelocytic, Acute
Neoplasm Proteins
Nuclear Proteins
Polymorphism, Restriction Fragment Length
Promyelocytic Leukemia Protein
Receptors, Retinoic Acid

Source

Open in PubMed

Identifiers

PMID: 7601459
DOI: 10.1016/0888-7543(95)80217-a

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7601459-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Reference Values

Repetitive Sequences, Nucleic Acid

Retinoic Acid Receptor alpha

Sequence Deletion