Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PML gene is linked to a megabase-scale insertion/deletion restriction fragment length polymorphism.

Genomics - 20 Mar 1995

Goy A, Passalaris T, Xiao Y H, Miller W H, Siegel D S, Zelenetz A D

Abstract excerpt

The PML gene located on chromosome band 15q22 is involved with the RAR alpha locus (17q21) in a balanced reciprocal translocation uniquely observed in acute promyelocytic leukemia. Physical mapping studies by pulsed-field gel electrophoresis revealed that the PML gene is flanked by two CpG islands that are separated by a variable distance in normal individuals. Several lines of evidence demonstrate that this is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Genes
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nuclear Proteins

Share to Polymorphism, Restriction Fragment Length

Share to Reference Values

Share to Repetitive Sequences, Nucleic Acid

Share to Sequence Deletion

Source

Identifiers

PMID: 7601459
DOI: 10.1016/0888-7543(95)80217-a

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PML gene is linked to a megabase-scale insertion/deletion restriction fragment length polymorphism.PMID 7601459Read ↗

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.Semantic proximity Read ↗

Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemiaSemantic proximity Read ↗

Mutations of the PML tumor suppressor gene in acute promyelocytic leukemiaSemantic proximity Read ↗

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17Semantic proximity Read ↗

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PMLSemantic proximity Read ↗

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.Semantic proximity Read ↗

Microarray, gene sequencing, and reverse transcriptase-polymerase chain reaction analyses of a cryptic PML-RARA translocation.Semantic proximity Read ↗

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosisSemantic proximity Read ↗

Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.Semantic proximity Read ↗

Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia.Semantic proximity Read ↗

Analysis of t(15;17) chromosomal breakpoint sequences in therapy‐related versus de novo acute promyelocytic leukemia: Association of DNA breaks with specific DNA motifs at <i>PML</i> and <i>RARA</i> lociSemantic proximity Read ↗

Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Molecular Cytogenetic Diagnosis in Haematological Malignancies".Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.