Article
Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling.
Development (Cambridge, England) - 1 Mar 1998
Adler P N, Charlton J, Liu J
Abstract excerpt
The adult cuticular wing of Drosophila is covered by an array of distally pointing hairs that reveals the planar polarity of the wing. We report here that mutations in dachsous disrupt this regular pattern, and do so by affecting frizzled signaling. dachsous encodes a large membrane protein that...
Topics
- Animals
- Body Patterning
- Cadherins
- Cell Adhesion
- Drosophila
- Drosophila Proteins
- Frizzled Receptors
- Gene Expression Regulation, Developmental
- Genes, Insect
- Insect Proteins
- Membrane Proteins
- Mosaicism
- Mutation
- Phenotype
- Receptors, G-Protein-Coupled
- Signal Transduction
- Wings, Animal