Article
Dominant negative expression of a cytoplasmically deleted mutant of XB/U-cadherin disturbs mesoderm migration during gastrulation in Xenopus laevis.
Mechanisms of development - 1 Jan 1996
Kühl M, Finnemann S, Binder O, Wedlich D
Abstract excerpt
XB/U-cadherin is a maternal Xenopus cadherin which mediates interblastomere adhesion in early embryogenesis. In order to explore its role in gastrulation, we expressed a cytoplasmic deletion mutant of XB/U-cadherin (XB delta c38) under the control of the CMV promoter in Xenopus embryos. This trun...
Topics
- Animals
- Cadherins
- Cell Movement
- Cytomegalovirus
- Gastrula
- Gene Expression Regulation, Developmental
- Genes, Dominant
- L Cells
- Mesoderm
- Mice
- Morphogenesis
- Nervous System
- Oocytes
- Phenotype
- Promoter Regions, Genetic
- Recombinant Fusion Proteins
- Sequence Deletion
- Xenopus Proteins