Article
Absence of the GluR2 receptor sensitizes mouse sympathetic neurons to nerve growth factor deprivation.
Neuroscience letters - 3 Mar 2000
Lourenssen S, Roder J C, Blennerhassett M G
Abstract excerpt
Over-activation of glutamate receptors is implicated in neurodegeneration. Using mice with a deletion in the GluR2 gene, we studied the sensitivity of sympathetic neurons to reduced levels of nerve growth factor (NGF), which can cause neuronal cell death. Under standard culture conditions of 50 ng/ml NGF, neurons from the superior cervical ganglion survived and grew equally well compared with wild type controls....
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