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Article

Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 1995

Liu Z, Lee A, Gilbert W

Abstract excerpt

The yeast gene KEM1 (also named SEP1/DST2/XRN1/RAR5) produces a G4-DNA-dependent nuclease that binds to G4 tetraplex DNA structure and cuts in a single-stranded region 5' to the G4 structure. G4-DNA generated from yeast telomeric oligonucleotides competitively inhibits the cleavage reaction, sugg...

Topics

Blotting, Southern
DNA, Fungal
Deoxyribonucleases
Exoribonucleases
Fungal Proteins
Genes, Fungal
Oligodeoxyribonucleotides
Phenotype
Plasmids
Restriction Mapping
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 7597069
DOI: 10.1073/pnas.92.13.6002
PMCID: PMC41630

Genes

XRN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7597069-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.PMID 7597069Read ↗

Identification of functional domains in the Sep1 protein (= Kem1, Xrn1), which is required for transition through meiotic prophase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of telomere metabolism by the RNA processing protein Xrn1.Semantic proximity Read ↗

NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase.Semantic proximity Read ↗

Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.Semantic proximity Read ↗

RAD51AP1 -deficiency in vertebrate cells impairs DNA replicationSemantic proximity Read ↗

Requirement of S. pombe exonuclease II, a homologue of S. cerevisiae Sep1, for normal mitotic growth and viability.Semantic proximity Read ↗

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read ↗

EXO1-A multi-tasking eukaryotic nuclease.Semantic proximity Read ↗

Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.Semantic proximity Read ↗

Tangeretin sensitizes SGS1-deficient cells by inducing DNA damage.Semantic proximity Read ↗

Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair.Semantic proximity Read ↗

Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.Semantic proximity Read ↗

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