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Article

Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 1995

Liu Z, Lee A, Gilbert W

Abstract excerpt

The yeast gene KEM1 (also named SEP1/DST2/XRN1/RAR5) produces a G4-DNA-dependent nuclease that binds to G4 tetraplex DNA structure and cuts in a single-stranded region 5' to the G4 structure. G4-DNA generated from yeast telomeric oligonucleotides competitively inhibits the cleavage reaction, suggesting that this enzyme may interact with yeast telomeres in vivo. Homozygous deletions of the KEM1 gene in yeast block...

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Identifiers

PMID: 7597069
DOI: 10.1073/pnas.92.13.6002
PMCID: PMC41630

Genes

XRN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening.PMID 7597069Read ↗

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Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read ↗

EXO1-A multi-tasking eukaryotic nuclease.Semantic proximity Read ↗

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