Article
Regulation of telomere metabolism by the RNA processing protein Xrn1.
Nucleic acids research - 20 Apr 2017
Cesena Daniele, Cassani Corinne, Rizzo Emanuela, Lisby Michael, Bonetti Diego, Longhese Maria Pia
Abstract excerpt
Telomeric DNA consists of repetitive G-rich sequences that terminate with a 3΄-ended single stranded overhang (G-tail), which is important for telomere extension by telomerase. Several proteins, including the CST complex, are necessary to maintain telomere structure and length in both yeast and mammals. Emerging evidence indicates that RNA processing factors play critical, yet poorly understood, roles in telomere...
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