Article
p53 proteins accumulated by heat stress associate with heat shock proteins HSP72/HSC73 in human glioblastoma cell lines.
Cancer letters - 25 Nov 1994
Matsumoto H, Shimura M, Omatsu T, Okaichi K, Majima H, Ohnishi T
Abstract excerpt
We investigated the accumulation of p53 proteins after heat stress and their association with HSP72/HSC73 using four human glioblastoma cell lines. Human glioblastoma cell lines U-87MG and A-172 exhibited no mutation in the region between the 2nd and 11th exons of the p53 gene, whereas A-7 and T9...
Topics
- Blotting, Western
- DNA, Neoplasm
- Exons
- Genes, p53
- Glioblastoma
- HSP70 Heat-Shock Proteins
- Hot Temperature
- Humans
- Mutation
- Polymerase Chain Reaction
- Precipitin Tests
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53