Article
5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus.
Experimental neurology - 1 Sept 1997
Lucchinetti C F, Kimmel D W, Pavelko K, Rodriguez M
Abstract excerpt
A multifocal inflammatory leukoencephalopathy is associated with the administration of 5-fluorouracil (5-FU), a pyrimidine analogue, and levamisole (LE), an immunomodulator, in patients receiving adjuvant therapy for colon cancer. Cerebral biopsy demonstrated features indistinguishable from multiple sclerosis. We tested whether administration of these agents directly resulted in inflammatory demyelination in mice...
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