Article
5-Fluorouracil and levamisole exacerbate demyelination in susceptible mice infected with Theiler's virus.
Experimental neurology - 1 Sept 1997
Lucchinetti C F, Kimmel D W, Pavelko K, Rodriguez M
Abstract excerpt
A multifocal inflammatory leukoencephalopathy is associated with the administration of 5-fluorouracil (5-FU), a pyrimidine analogue, and levamisole (LE), an immunomodulator, in patients receiving adjuvant therapy for colon cancer. Cerebral biopsy demonstrated features indistinguishable from multi...
Topics
- Adjuvants, Immunologic
- Animals
- Antimetabolites, Antineoplastic
- Demyelinating Diseases
- Female
- Fluorouracil
- Genetic Predisposition to Disease
- Levamisole
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Myelin Sheath
- Poliomyelitis
- Reference Values
- Spinal Cord
- Theilovirus