Article
An erythroid and megakaryocytic common precursor cell line (B1647) expressing both c-mpl and erythropoietin receptor (Epo-R) proliferates and modifies globin chain synthesis in response to megakaryocyte growth and development factor (MGDF) but not to erythropoietin (Epo).
British journal of haematology - 1 Sept 1997
Bonsi L, Grossi A, Strippoli P, Tumietto F, Tonelli R, Vannucchi A M, Ronchi A, Ottolenghi S, Visconti G, Avanzi G C, Pegoraro L, Bagnara G P
Abstract excerpt
A human megakaryocyte cell line (B1647) has been established from bone marrow cells obtained from a patient with acute myelogenous leukaemia (FAB M2). The cells were CD34-, CD33+, HLA-DR+, CD38+, and expressed the immunophenotypic markers of the megakaryocyte lineage (CD41 and von Willebrand factor). Moreover the cells expressed the c-mpl (thrombopoietin receptor) mRNA and protein. On the other hand, the B1647...
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