An erythroid and megakaryocytic common precursor cell line (B1647) expressing both c-mpl and erythropoietin receptor (Epo-R) proliferates and modifies globin chain synthesis in response to megakaryocyte growth and development factor (MGDF) but not to erythropoietin (Epo).

doi:10.1046/j.1365-2141.1997.2793096.x

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Article

An erythroid and megakaryocytic common precursor cell line (B1647) expressing both c-mpl and erythropoietin receptor (Epo-R) proliferates and modifies globin chain synthesis in response to megakaryocyte growth and development factor (MGDF) but not to erythropoietin (Epo).

British journal of haematology - 1 Sept 1997

Bonsi L, Grossi A, Strippoli P, Tumietto F, Tonelli R, Vannucchi A M, Ronchi A, Ottolenghi S, Visconti G, Avanzi G C, Pegoraro L, Bagnara G P

Abstract excerpt

A human megakaryocyte cell line (B1647) has been established from bone marrow cells obtained from a patient with acute myelogenous leukaemia (FAB M2). The cells were CD34-, CD33+, HLA-DR+, CD38+, and expressed the immunophenotypic markers of the megakaryocyte lineage (CD41 and von Willebrand fact...

Topics

Cell Division
Cell Line
Cytokines
Erythroid Precursor Cells
Erythropoietin
Globins
Humans
Megakaryocytes
Phenotype
RNA, Messenger
Receptors, Erythropoietin
Serotonin
Thrombopoietin

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PMID: 9332307
DOI: 10.1046/j.1365-2141.1997.2793096.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9332307-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.