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Article

COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus.

The Journal of cell biology - 1 Nov 1995

Lorenzen J A, Dadabay C Y, Fischer E H

Abstract excerpt

The noncatalytic domain of the human T cell protein tyrosine phosphatase (TCPTP) is alternatively spliced to generate a 45-kD form, p45TC, and a 48-kD form, p48TC (Champion-Arnaud et al., 1991; Mosinger et al., 1992). This manuscript concerns structural motifs in the noncatalytic segment of the enzyme responsible for targeting the two forms to different subcellular compartments. Endogenous and transiently...

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Identifiers

PMID: 7593185
DOI: 10.1083/jcb.131.3.631
PMCID: PMC2120615

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