p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.

doi:10.1016/j.mce.2020.110719

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Article

p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.

Molecular and cellular endocrinology - 5 Apr 2020

Citterio Cintia E, Siffo Sofia, Moya Christian M, Pio Mauricio Gomes, Molina Maricel F, Scheps Karen G, Rey Osvaldo A, Arvan Peter, Rivolta Carina M, Targovnik Héctor M

Abstract excerpt

Thyroglobulin (TG), a large glycosylated protein secreted by thyrocytes into the thyroid follicular lumen, plays an essential role in thyroid hormone biosynthesis. Rattus norvegicus TG (rTG) is encoded by a large single copy gene, 186-kb long, located on chromosome 7 composed of 48 exons encoding a 8461-kb mRNA. Although the TG gene displays sequence variability, many missense mutations do not impose any adverse...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary
Glycoside Hydrolases
HEK293 Cells
Humans
Intracellular Space
Male
Mutagenesis
Mutant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Domains

Protein Multimerization

Protein Structure, Secondary

Rats, Wistar

Thyroglobulin

Source

Open in PubMed

Identifiers

PMID: 31972331
DOI: 10.1016/j.mce.2020.110719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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