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Article

p.L571P in the linker domain of rat thyroglobulin causes intracellular retention.

Molecular and cellular endocrinology - 5 Apr 2020

Citterio Cintia E, Siffo Sofia, Moya Christian M, Pio Mauricio Gomes, Molina Maricel F, Scheps Karen G, Rey Osvaldo A, Arvan Peter, Rivolta Carina M, Targovnik Héctor M

Abstract excerpt

Thyroglobulin (TG), a large glycosylated protein secreted by thyrocytes into the thyroid follicular lumen, plays an essential role in thyroid hormone biosynthesis. Rattus norvegicus TG (rTG) is encoded by a large single copy gene, 186-kb long, located on chromosome 7 composed of 48 exons encoding a 8461-kb mRNA. Although the TG gene displays sequence variability, many missense mutations do not impose any adverse...

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PMID: 31972331
DOI: 10.1016/j.mce.2020.110719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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