Article
Detection of a Novel gyrB Mutation Associated With Fluoroquinolone-Nonsusceptible Salmonella enterica serovar Typhimurium Isolated From a Bloodstream Infection in Ghana.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Mar 2016
Al-Emran Hassan M, Heisig Anke, Dekker Denise, Adu-Sarkodie Yaw, Cruz Espinoza Ligia Maria, Panzner Ursula, von Kalckreuth Vera, Marks Florian, Park Se Eun, Sarpong Nimako, May Jürgen, Heisig Peter
Abstract excerpt
A multidrug-resistant Salmonella enterica serovar Typhimurium with reduced susceptibility to ciprofloxacin was isolated from the blood of a hospitalized child in Ghana. DNA sequencing identified a novel gyrB mutation at codon 466 (Glu466Asp). An increase in fluoroquinolone susceptibility after the introduction of a wild-type gyrB(+) allele demonstrated that the gyrB466 mutation had a direct effect on...
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