Article
The length of the CTLA-4 microsatellite (AT)N-repeat affects the risk for type 1 diabetes. Diabetes Incidence in Sweden Study Group.
Autoimmunity - 1 Oct 2000
Lowe R M, Graham J, Sund G, Kockum I, Landin-Olsson M, Schaefer J B, Törn C, Lernmark A, Dahlquist G
Abstract excerpt
CTLA-4 is important to down-regulating T cell responses and has been implicated in type 1 (insulin dependent) diabetes mellitus in both linkage and association studies. The aim of our study was to relate the polymorphic (AT)n microsatellite in the 3' untranslated sequence of the CTLA-4 gene to diabetes risk. We studied 616 consecutively diagnosed 0-34 year-old Swedish patients and 502 matched controls by...
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