Article
Phenotype of dystrophinopathy in old mdx mice.
The Anatomical record - 1 May 1995
Lefaucheur J P, Pastoret C, Sebille A
Abstract excerpt
BACKGROUND: Mdx mutant mice, like patients with Duchenne Muscular Dystrophy (DMD), lack dystrophin, a subsarcolemmal protein, that results in myofiber necrosis. However young mdx mice, in contrast to DMD children, exhibit a successful muscle regeneration and not an extensive fibrosis. METHODS: Old mdx mice were monitored clinically up to their spontaneous death, and most of their organs were studied...
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