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Article

Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome: involvement of Fas-Fas ligand interaction.

European journal of immunology - 1 Sept 1995

Kanagawa O, Vaupel B A, Korsmeyer S J, Russell J H

Abstract excerpt

Murine acquired immunodeficiency syndrome (MAIDS) is caused by a defective murine leukemia virus. The disease is characterized by abnormal lymphoproliferation, impaired T and B cell function and aberrant regulation of cytokines. Both T and B lymphocytes show activated phenotypes, but undergo apoptotic death with characteristic DNA fragmentation. These results indicate the presence of a continuous activation death...

Topics

Animals
Apoptosis
B-Lymphocytes
Cells, Cultured
Glucan Endo-1,3-beta-D-Glucosidase
Immunophenotyping
Ligands
Mice
Mice, Inbred C57BL
Mice, Transgenic
Murine Acquired Immunodeficiency Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

T-Lymphocytes

fas Receptor

Source

Identifiers

PMID: 7589105
DOI: 10.1002/eji.1830250902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7589105-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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