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T cell apoptosis characterizes severe Covid-19 disease

22 Jan 2022

Abstract excerpt

Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized that SARS-CoV-2 infection-mediated lymphopenia could also be related to T cell apoptosis. By comparing intensive care unit (ICU) and non-ICU COVID-19 patients with age-matched healthy donors, we found a strong positive correlation between...

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PMID: 35066575
DOI: 10.1038/s41418-022-00936-x

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