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Article

HLA class II-restricted recognition of common tumor epitopes on human melanoma cells by CD4+ melanoma-infiltrating lymphocytes.

European journal of immunology - 1 Oct 1995

Le Dréan E, Gervois N, Diez E, Semana G, Dreno B, Jotereau F

Abstract excerpt

CD4+ T cell clones derived from lymphocytes infiltrating four human melanomas specifically recognized melanoma-derived tumor epitopes as shown by secretion of tumor necrosis factor (TNF) in vitro upon interaction with autologous melanoma cells, whereas they did not recognize HLA class II-expressing autologous lymphoblasts or HLA class II mismatched allogeneic melanoma cells. Specificity was further established by...

Topics

Alleles
Animals
Antibodies, Monoclonal
Antigens, Neoplasm
CD4-Positive T-Lymphocytes
Cattle
Clone Cells
Genes, MHC Class II
HLA-D Antigens
Humans
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes, Tumor-Infiltrating

Lymphotoxin-alpha

Melanoma

Source

Identifiers

PMID: 7589064
DOI: 10.1002/eji.1830251003

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7589064-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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