Article
A p16 <sup>INK4a</sup> -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma
1 Sept 1995
Abstract excerpt
A mutated cyclin-dependent kinase 4 (CDK4) was identified as a tumor-specific antigen recognized by HLA-A2. 1-restricted autologous cytolytic T lymphocytes (CTLs) in a human melanoma. The mutated CDK4 allele was present in autologous cultured melanoma cells and metastasis tissue, but not in the patient's lymphocytes. The mutation, an arginine-to-cysteine exchange at residue 24, was part of the CDK4 peptide...
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