Article
T-cell receptor repertoire of lymphocytes infiltrating cutaneous melanoma is predominated by V alpha specificities present in T-cells of normal human skin.
Cancer research - 1 Sept 1994
Strohal R, Paucz L, Pehamberger H, Stingl G
Abstract excerpt
Lymphocytes infiltrating solid tumors can be propagated in vitro with interleukin 2 and are then capable, as CD8+ cytotoxic T-cells, of specific lysis of autologous tumor targets in a class I-restricted manner. Since the specificity of these cells is determined by their T-cell receptor (TCR) conf...
Topics
- Adult
- Aged
- Antigens, Neoplasm
- Base Sequence
- CD4 Antigens
- Female
- Humans
- Lymphocytes, Tumor-Infiltrating
- Male
- Melanoma
- Melanoma-Specific Antigens
- Middle Aged
- Molecular Sequence Data
- Neoplasm Proteins
- Phenotype
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell, alpha-beta
- Skin