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Article

STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo.

The EMBO journal - 16 Oct 1995

Zufferey R, Knauer R, Burda P, Stagljar I, te Heesen S, Lehle L, Aebi M

Abstract excerpt

N-linked glycosylation is a ubiquitous protein modification, and is essential for viability in eukaryotic cells. A lipid-linked core-oligosaccharide is assembled at the membrane of the endoplasmic reticulum and transferred to selected asparagine residues of nascent polypeptide chains by the oligosaccharyl transferase (OTase) complex. Based on the synthetic lethal phenotype of double mutations affecting the...

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Identifiers

PMID: 7588624
DOI: 10.1002/j.1460-2075.1995.tb00178.x
PMCID: PMC394598

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo.PMID 7588624Read ↗

The STT3 protein is a component of the yeast oligosaccharyltransferase complex.Semantic proximity Read ↗

Studies on the N-glycosylation of the subunits of oligosaccharyl transferase in Saccharomyces cerevisiae.Semantic proximity Read ↗

The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex.Semantic proximity Read ↗

A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro.Semantic proximity Read ↗

High-level expression of the Toxoplasma gondii STT3 gene is required for suppression of the yeast STT3 gene mutation.Semantic proximity Read ↗

Arabidopsis thaliana ALG3 mutant synthesizes immature oligosaccharides in the ER and accumulates unique N-glycans.Semantic proximity Read ↗

Cellular Consequences of Diminished Protein O-Mannosyltransferase Activity in Baker's Yeast.Semantic proximity Read ↗

Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase.Semantic proximity Read ↗

Insight into functional aspects of Stt3p, a subunit of the oligosaccharyl transferase. Evidence for interaction of the N-terminal domain of Stt3p with the protein kinase C cascade.Semantic proximity Read ↗

Studies on the function of oligosaccharyl transferase subunits. Stt3p is directly involved in the glycosylation process.Semantic proximity Read ↗

Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferasesSemantic proximity Read ↗

New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus.Semantic proximity Read ↗

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