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Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases

23 Jul 2009

Abstract excerpt

Asparagine-linked glycosylation is catalysed by oligosaccharyltransferase (OTase). In Trypanosoma brucei OTase activity is catalysed by single-subunit enzymes encoded by three paralogous genes of which TbSTT3B and TbSTT3C can complement a yeast Deltastt3 mutant. The two enzymes have overlapping but distinct peptide acceptor specificities, with TbSTT3C displaying an enhanced ability to glycosylate sites flanked by...

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PMID: 19629045
DOI: 10.1038/emboj.2009.203

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