Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning.

Developmental biology - 1 Feb 2006

Seo Kwang Won, Wang Yingdi, Kokubo Hiroki, Kettlewell Jae R, Zarkower David A, Johnson Randy L

Abstract excerpt

Dmrt2 is expressed in the dermomyotome of developing vertebrate somites. To determine the role of Dmrt2 during mouse embryonic development, we generated a null mutation of Dmrt2 via homologous recombination in embryonic stem cells. Dmrt2 heterozygous mice derived from these cells are phenotypically normal. However, Dmrt2 homozygotes die soon after birth. The cause of death is likely due to abnormal rib and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo Loss
Share to Gonads
Share to MyoD Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myogenic Regulatory Factor 5

Share to Myogenic Regulatory Factors

Share to PAX3 Transcription Factor

Share to Sex Differentiation

Share to Somites

Source

Identifiers

PMID: 16387292
DOI: 10.1016/j.ydbio.2005.11.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning.PMID 16387292Read ↗

DMRT1: An Ancient Sexual Regulator Required for Human GonadogenesisSemantic proximity Read ↗

mRNA Expression Analysis and the Molecular Basis of Neonatal Testis Defects in <i>Dmrt1</i> Mutant MiceSemantic proximity Read ↗

The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.Semantic proximity Read ↗

A Confirmatory Case of Severe Spondylocostal Dysostosis Caused by Biallelic Loss-of-Function of DMRT2.Semantic proximity Read ↗

Mice mutant in the DM domain gene Dmrt4 are viable and fertile but have polyovular follicles.Semantic proximity Read ↗

Development and patterning of rib primordia are dependent on associated musculature.Semantic proximity Read ↗

DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.Semantic proximity Read ↗

Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testisSemantic proximity Read ↗

Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stageSemantic proximity Read ↗

The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript.Semantic proximity Read ↗

Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.Semantic proximity Read ↗

Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.