Article
Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.
Developmental biology - 15 Aug 1997
Yoon J K, Olson E N, Arnold H H, Wold B J
Abstract excerpt
Three different null alleles of the myogenic bHLH gene MRF4/herculin/Myf-6 were created recently. The three alleles were similar in design but were surprisingly different in the intensity of their phenotypes, which ranged from complete viability of homozygotes to complete lethality. One possible explanation for these differences is that each mutation altered expression from the nearby Myf-5 gene to a different...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.