Article
H-ras oncogene mutation spectra in B6C3F1 and C57BL/6 mouse liver tumors provide evidence for TCDD promotion of spontaneous and vinyl carbamate-initiated liver cells.
Carcinogenesis - 1 Aug 1995
Watson M A, Devereux T R, Malarkey D E, Anderson M W, Maronpot R R
Abstract excerpt
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent environmental toxin which has been found to be non-genotoxic in short term in vitro tests but strongly carcinogenic in two stage models of hepatocellular carcinogenesis in female rats. Many recent studies have shown that after treatment of mi...
Topics
- Animals
- Base Sequence
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Polychlorinated Dibenzodioxins
- Urethane