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Article

Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.

Cancer research - 1 Dec 1995

Vaury C, Lainé R, Noguiez P, de Coppet P, Jaulin C, Praz F, Pompon D, Amor-Guéret M

Abstract excerpt

We investigated the transcriptional regulation of cytochrome P450 1A1 (CYP1A1) gene in human lymphoblastoid B cells and report that a high inducibility of CYP1A1 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin is associated with glutathione S-transferase M1 (GSTM1) null genotype, whereas the presence of at least one GSTM1 allele is correlated with induction of only low levels of CYP1A1 mRNA by...

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Identifiers

PMID: 7585625

Genes

GSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.PMID 7585625Read ↗

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Genetic polymorphism at the glutathione S-transferase (GST) P1 locus is a breast cancer risk modifier.Semantic proximity Read ↗

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