Article
Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.
Cancer research - 1 Dec 1995
Vaury C, Lainé R, Noguiez P, de Coppet P, Jaulin C, Praz F, Pompon D, Amor-Guéret M
Abstract excerpt
We investigated the transcriptional regulation of cytochrome P450 1A1 (CYP1A1) gene in human lymphoblastoid B cells and report that a high inducibility of CYP1A1 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin is associated with glutathione S-transferase M1 (GSTM1) null genotype, wherea...
Topics
- Base Sequence
- Cell Line, Transformed
- Cytochrome P-450 Enzyme System
- DNA Primers
- Enzyme Induction
- Gene Expression Regulation, Enzymologic
- Genotype
- Glutathione Transferase
- Humans
- Lymphoma, B-Cell
- Molecular Sequence Data
- Polychlorinated Dibenzodioxins
- Tumor Cells, Cultured