Article
Association between glutathione S-transferase genotypes and Hodgkin's lymphoma risk and prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2003
Hohaus Stefan, Massini Giuseppina, D'Alo' Francesco, Guidi Francesco, Putzulu Rossana, Scardocci Alessandra, Rabi Andras, Di Febo Anna Laura, Voso Maria Teresa, Leone Giuseppe
Abstract excerpt
PURPOSE: The interplay between genetic susceptibility and exposure to carcinogens has been shown to be involved in the etiology of many solid tumors. We studied the frequency and clinical correlates of polymorphisms resulting in deletions of two genes involved in the detoxification of potentially carcinogenic agents, glutathione S-transferase (GST)-M1 and GSTT1 in patients with Hodgkin's lymphoma (HL)....
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