Article
Use of a "replication-restricted" herpes virus to treat experimental human malignant mesothelioma.
Cancer research - 1 Feb 1997
Kucharczuk J C, Randazzo B, Chang M Y, Amin K M, Elshami A A, Sterman D H, Rizk N P, Molnar-Kimber K L, Brown S M, MacLean A R, Litzky L A, Fraser N W, Albelda S M, Kaiser L R
Abstract excerpt
Modified, nonneurovirulent herpes simplex viruses (HSVs) have shown promise in the treatment of brain tumors. However, HSV-1 can infect and lyse a wide range of cell types. In this report, we show that HSV-1716, a mutant lacking both copies of the gene coding ICP-34.5, can effectively treat a localized i.p. malignancy. Human malignant mesothelioma cells supported the growth of HSV-1716 and were efficiently lysed...
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