Article
CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1995
Truitt K E, Shi J, Gibson S, Segal L G, Mills G B, Imboden J B
Abstract excerpt
CD28, a cell-surface molecule expressed by T cells, delivers costimulatory signals during the activation of T cells by Ag. Stimulation of CD28 induces its association with phosphatidylinositol 3'-kinase (PI3-K), raising the possibility that PI3-K plays a critical role in CD28 signaling. We find, however, that wortmannin, a potent inhibitor of PI3-K, does not block CD28-mediated costimulation of Jurkat (a human T...
Topics
- Androstadienes
- Animals
- CD28 Antigens
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Female
- Humans
- Interleukin-2
- Mice
- Mice, Inbred C57BL
- Mutation