Article
Imprinting and anticipation. Are they relevant to genetic studies of schizophrenia?
The British journal of psychiatry : the journal of mental science - 1 May 1994
Asherson P, Walsh C, Williams J, Sargeant M, Taylor C, Clements A, Gill M, Owen M, McGuffin P
Abstract excerpt
Among 29 multiply affected pedigrees, age of onset among parents and offspring was examined for evidence of both anticipation and genomic imprinting. The results do not suggest that either mechanism is operating in schizophrenia, but only very large effects can be confidently excluded.
Topics
- Adult
- Age Factors
- Female
- Gene Expression Regulation
- Genomic Imprinting
- Humans
- Male
- Models, Genetic
- Phenotype
- Psychotic Disorders
- Schizophrenia
- Schizophrenic Psychology