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Article

Isoforms of human HGF and their biological activities.

EXS - 1 Jan 1993

Chan A, Rubin J, Bottaro D, Hirschfield D, Chedid M, Aaronson S A

Abstract excerpt

Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. It is produced by stromal fibroblasts and acts as a mitogen for a variety of target cells. Scatter factor, a stimulant of epithelial and vascular endothelial cell motility, is the same as HGF. HGF mediates its effects by activation of a membrane-spanning tyrosine kinase, recently identified as the...

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Source

Identifiers

PMID: 8380745

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isoforms of human HGF and their biological activities.PMID 8380745Read ↗

Molecular characteristics of HGF and the gene, and its biochemical aspects.Semantic proximity Read ↗

Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.Semantic proximity Read ↗

Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains.Semantic proximity Read ↗

In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis.Semantic proximity Read ↗

Evidence for the identity of human scatter factor and human hepatocyte growth factor.Semantic proximity Read ↗

Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa.Semantic proximity Read ↗

Identification of a novel variant hepatocyte growth factor secreted by spleen-derived stromal cells.Semantic proximity Read ↗

The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review).Semantic proximity Read ↗

Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein.Semantic proximity Read ↗

Targeting the hepatocyte growth factor/Met pathway in cancer.Semantic proximity Read ↗

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.Semantic proximity Read ↗

Gene expression and regulation of HGF-SF.Semantic proximity Read ↗

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