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Article

The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis

31 Dec 2008

Abstract excerpt

Angiogenesis in tumors is driven by multiple growth factors that activate receptor tyrosine kinases. An important driving force of angiogenesis in solid tumors is signaling through vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). Angiogenesis inhibitors that target this signaling pathway are now in widespread use for the treatment of cancer. However, when used alone, inhibitors of VEGF/VEGFR...

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Share to Cancer Mechanisms and Therapy
Share to Hepatocellular Carcinoma Treatment and Prognosis
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Identifiers

PMID: 19123972
DOI: 10.5483/bmbrep.2008.41.12.833

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