Article
Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.
The EMBO journal - 1 Jul 1992
Lokker N A, Mark M R, Luis E A, Bennett G L, Robbins K A, Baker J B, Godowski P J
Abstract excerpt
Hepatocyte growth factor (HGF) is a potent mitogen for parenchymal liver, epithelial and endothelial cells. Structurally, it has similarities to kringle-containing serine proteases, although it does not possess proteolytic activity. A structure-activity relationship study of human HGF was performed by functional analysis of HGF substitution and deletion variants. Analysis of HGF variants was accomplished by...
Topics
- Animals
- Blotting, Western
- Cells, Cultured
- Computer Simulation
- DNA
- Endopeptidases
- Female
- Growth Substances
- Hepatocyte Growth Factor
- Humans
- Models, Molecular