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Article

Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.

The EMBO journal - 1 Jul 1992

Lokker N A, Mark M R, Luis E A, Bennett G L, Robbins K A, Baker J B, Godowski P J

Abstract excerpt

Hepatocyte growth factor (HGF) is a potent mitogen for parenchymal liver, epithelial and endothelial cells. Structurally, it has similarities to kringle-containing serine proteases, although it does not possess proteolytic activity. A structure-activity relationship study of human HGF was performed by functional analysis of HGF substitution and deletion variants. Analysis of HGF variants was accomplished by...

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Identifiers

PMID: 1321034
DOI: 10.1002/j.1460-2075.1992.tb05315.x
PMCID: PMC556725

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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