Article
Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population.
Transplant immunology - 1 Jun 1995
Lagoo-Deenadayalan S, Lagoo A S, Lemons J A, Lorenz H M, Bass J D, McDaniel D O, Hardy K J, Barber W H
Abstract excerpt
Previous studies have shown that post-transplantation infusion of donor specific bone marrow following a non-specific potent immunosuppressive agent such as antilymphocyte globulin (ALG) can significantly enhance graft survival compared to ALG alone. This enhancement remains variable and is thought to occur through the induction of specific partial tolerance to the renal allograft, but the underlying cellular...
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